ABSTRACT
OBJECTIVE:To compare the vitro dissolution between glimepiride tablets and glimepiride dropping pills.METHODS:In vitro dissolution test was conducted in accordance with the related methods specified in Chinese Pharmacopeia(2005 Edition)with the content of glimepiride determined by UV spectrophotometry.The accumulative dissolution percentages of the two formulations were computed respectively.The dissolution parameters(T50,Td,m,r)were fitted using Weibull equation and the data about the accumulative dissolution percentage were analyzed.RESULTS:There were significant differences between glimepiride tablets and glimepiride dropping pills in dissolution rate(18.70% vs.40.25% at 5 min and 90.32%vs.99.96% at 45 min,P
ABSTRACT
AIM: To elucidate the mechanism of fibrin in cholesterol gallstone disease. METHODS: Hemostatic indices were systemically examined in the gallbladder bile obtained from 26 patients with gallstones and 17 without gallstones. RESULTS: Significant increases were found in tissue factor (TF) concentration( P